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  1. X-linked myotubular myopathy (XLMTM) is a rare, life-threatening congenital myopathy. Most (80%) children with XLMTM have profound muscle weakness and hypotonia at birth resulting in severe respiratory insuffi...

    Authors: Robert J. Graham, Reshma Amin, Nadir Demirel, Lisa Edel, Charlotte Lilien, Victoria MacBean, Gerrard F. Rafferty, Hemant Sawnani, Carola Schön, Barbara K. Smith, Faiza Syed, Micaela Sarazen, Suyash Prasad, Salvador Rico and Geovanny F. Perez
    Citation: Respiratory Research 2024 25:342
  2. Chronic obstructive pulmonary disease (COPD) and asthma can be treated with inhaled corticosteroids (ICS) delivered by low climate impact inhalers (dry powder inhalers) or high climate impact inhalers (pressur...

    Authors: Barbara Bonnesen, Josefin Eklöf, Tor Biering-Sørensen, Daniel Modin, Marc Miravitlles, Alexander G. Mathioudakis, Pradeesh Sivapalan and Jens-Ulrik Staehr Jensen
    Citation: Respiratory Research 2024 25:339
  3. The WHO recently published a Tobacco Knowledge Summary (TKS) synthesizing current evidence on tobacco and COPD, aiming to raise awareness among a broad audience of health care professionals. Furthermore, it ca...

    Authors: Wenying Lu, Rebekka Aarsand, Kerstin Schotte, Jing Han, Elizaveta Lebedeva, Elena Tsoy, Nino Maglakelidze, Joan B Soriano, Werner Bill, David M G Halpin, M. Patricia Rivera, Kwun M Fong, Hasmeena Kathuria, Arzu YorgancıoÄŸlu, Monika Gappa, David CL Lam…
    Citation: Respiratory Research 2024 25:338
  4. Obstructive lung disease (OLD) is increasingly prevalent among persons living with HIV (PLWH). However, the role of proteases in HIV-associated OLD remains unclear.

    Authors: Sarah Samorodnitsky, Monica Kruk, Eric F. Lock, Ken M. Kunisaki, Alison Morris, Janice M. Leung, Danielle Weise, Subina Mehta, Laurie L. Parker, Pratik D. Jagtap, Timothy J. Griffin and Chris H. Wendt
    Citation: Respiratory Research 2024 25:337
  5. Particulate matter with a diameter of < 2.5 Î¼m (PM2.5) influences gene regulation via DNA methylation; however, its precise mechanism of action remains unclear. Thus, this study aimed to examine the connection be...

    Authors: Hyun Woo Ji, Jieun Kang, Hwan-Cheol Kim, Junghee Jung, Seon-Jin Lee, Ji Ye Jung and Sei Won Lee
    Citation: Respiratory Research 2024 25:335
  6. The internet is a common source of health information for patients and caregivers. To date, content and information quality of YouTube videos on sarcoidosis has not been studied. The aim of our study was to in...

    Authors: Katharina Buschulte, Sarah El-Hadi, Philipp Höger, Claudia Ganter, Marlies Wijsenbeek, Nicolas Kahn, Katharina Kriegsmann, Gillian C. Goobie, Christopher J. Ryerson, Markus Polke, Franziska Trudzinski and Michael Kreuter
    Citation: Respiratory Research 2024 25:334
  7. The Global Initiative for Chronic Obstructive Lung Disease 2023 revision proposed that chronic obstructive pulmonary disease (COPD) has various etiologies including infections (COPD-I), such as tuberculosis an...

    Authors: Bo-Guen Kim, Sun Hye Shin, Sun-Kyung Lee, Sang-Heon Kim and Hyun Lee
    Citation: Respiratory Research 2024 25:333
  8. Understanding the characteristics of pulmonary resistance and elastance in relation to the location of airway narrowing, e.g., tracheal stenosis vs. intrapulmonary airway obstruction, will help us understand l...

    Authors: Yuto Yasuda, Geoffrey N. Maksym, Lu Wang, Pasquale Chitano and Chun Y. Seow
    Citation: Respiratory Research 2024 25:332
  9. Over the past three decades, our understanding of sleep apnea in women has advanced, revealing disparities in pathophysiology, diagnosis, and treatment compared to men. However, no real-life study to date has ...

    Authors: Celia Vidal, Fanny Bertelli, Jean-Pierre Mallet, Raphael Gilson, Jean-Christian Borel, Frédéric Gagnadoux, Arnaud Bourdin, Nicolas Molinari and Dany Jaffuel
    Citation: Respiratory Research 2024 25:331
  10. Vascular endothelial damage is involved in the development and exacerbation of ventilator-induced lung injury (VILI). Pulmonary endothelial glycocalyx and neutrophil extracellular traps (NETs) are endothelial ...

    Authors: Kenichiro Kikuchi, Satoshi Kazuma and Michiaki Yamakage
    Citation: Respiratory Research 2024 25:330
  11. Preserved Ratio Impaired Spirometry (PRISm) is considered to be a precursor of chronic obstructive pulmonary disease. Radiomics nomogram can effectively identify the PRISm subjects from non-COPD subjects, espe...

    Authors: TaoHu Zhou, Yu Guan, XiaoQing Lin, XiuXiu Zhou, Liang Mao, YanQing Ma, Bing Fan, Jie Li, ShiYuan Liu and Li Fan
    Citation: Respiratory Research 2024 25:329
  12. The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension (PAH). While em...

    Authors: Lingling Yan, Xiaofei Luo, Chengcheng Hang, YuWang, Ziming Zhang, Shanshan Xu and Lizhong Du
    Citation: Respiratory Research 2024 25:328
  13. Asthma, a prevalent chronic inflammatory disorder, is shaped by a multifaceted interplay between genetic susceptibilities and environmental exposures. Despite strides in deciphering its pathophysiological land...

    Authors: Dihui Zhang, Xiaowei Pu, Man Zheng, Guanghui Li and Jia Chen
    Citation: Respiratory Research 2024 25:327
  14. In this study, we investigated whether neural precursor cell–expressed developmentally down-regulated gene 4-like (NEDD4L) is the E3 enzyme of angiotensin-converting enzyme 2 (ACE2) and whether NEDD4L degrades...

    Authors: Rui Wang, Rui Wang, Siqi Zhou, Tianya Liu, Jingjing Dang, Qianmin Chen, Jingyu Chen and Zhiping Wang
    Citation: Respiratory Research 2024 25:326
  15. Cough remains a persistent symptom in patients with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs). To inform future research, treatment and care models, we conducted the first...

    Authors: Rhiannon Green, Michael Baldwin, Nick Pooley, Kate Misso, Maureen PMH Rutten-van Mölken, Nina Patel and Marlies S. Wijsenbeek
    Citation: Respiratory Research 2024 25:325

    The Correction to this article has been published in Respiratory Research 2025 26:185

  16. Cobalt (Co) is a metal which is widely used in the industrial production. The previous studies found the toxic effects of environmental Co exposure on multiple organs. However, the correlation of blood Co conc...

    Authors: Fei Tang, Hong-Yan Liu, Qi-Yuan He, Ying Liu, Li-Ping Lv, Jun Fei and Lin Fu
    Citation: Respiratory Research 2024 25:324
  17. Complicated pleural infection comprises of complex effusions and empyema. When tube thoracostomy is ineffective, treatment options include surgical drainage, deloculation and decortication or intrapleural fibr...

    Authors: Jaewon Chang, Ben Indja, Jesse King, Stephanie Chan and Campbell D. Flynn
    Citation: Respiratory Research 2024 25:323
  18. Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disease characterized by emphysema and chronic bronchitis and a leading cause of mortality worldwide. COPD is commonly associated with sev...

    Authors: Lynne Faherty, William Z. Zhang, Mays M. Salih, Elektra K. Robinson, Elizabeth Perez, Kihwan Kim, Susan Carpenter and Suzanne M. Cloonan
    Citation: Respiratory Research 2024 25:322
  19. Mitochondria is prone to oxidative damage by endogenous and exogenous sources of free radicals, including particulate matter (PM). Given the role of mitochondria in inflammatory disorders, such as asthma and c...

    Authors: Ju Chang-Chien, Jing-Long Huang, Hui-Ju Tsai, Shih-Ling Wang, Ming-Ling Kuo and Tsung-Chieh Yao
    Citation: Respiratory Research 2024 25:321
  20. Iatrogenic pneumothorax is a relevant complication of computed tomography (CT)-guided percutaneous lung biopsy. The aim of the present study was to analyze the prognostic significance of texture analysis, emph...

    Authors: Jakob Leonhardi, Ulrike Dahms, Benedikt Schnarkowski, Manuel Florian Struck, Anne-Kathrin Höhn, Sebastian Krämer, Sebastian Ebel, Gordian Prasse, Armin Frille, Timm Denecke and Hans-Jonas Meyer
    Citation: Respiratory Research 2024 25:320
  21. Currently, there is conflicting information and guidance on the effective management of Alpha 1 Antitrypsin Deficiency (AATD). Establishing a consensus of assessment and disease management specific to AATD is ...

    Authors: Marc Miravitlles, Alice M. Turner, Maria Sucena, Jean-François Mornex, Timm Greulich, Marion Wencker and N. Gerard McElvaney
    Citation: Respiratory Research 2024 25:318
  22. Basal cells (BCs) are bronchial progenitor/stem cells that can regenerate injured airway that, in smokers, may undergo malignant transformation. As a model for early stages of lung carcinogenesis, we set out t...

    Authors: Olsida Zefi, Spencer Waldman, Ava Marsh, Miao Kevin Shi, Yosef Sonbolian, Batbayar Khulan, Taha Siddiqui, Aditi Desai, Dhruv Patel, Aham Okorozo, Samer Khader, Jay Dobkin, Ali Sadoughi, Chirag Shah, Simon Spivack and Yakov Peter
    Citation: Respiratory Research 2024 25:317
  23. Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev in the trea...

    Authors: Qiang Meng, Linhong Song, Hui Wang, Gang Wang and Gengxu Zhou
    Citation: Respiratory Research 2024 25:316
  24. Chronic obstructive pulmonary disease (COPD) is a frequent cause of morbidity and mortality. Dysregulated and enhanced immune-inflammatory responses have been described in COPD. Recent data showed impaired imm...

    Authors: Simonetta Baraldo, Matteo Bonato, Sebastiano Cassia, Paolo Casolari, Laura De Ferrari, Mariaenrica Tiné, Federico Baraldi, Tommaso Bigoni, Anna Maria Riccio, Fulvio Braido, Marina Saetta, Alberto Papi and Marco Contoli
    Citation: Respiratory Research 2024 25:315
  25. While asthma exacerbations remain a major challenge in patient management, few animal models exist to explore the underlying mechanisms. Here, we established an animal model of asthma that can be used to study...

    Authors: Benoit Allard, Olga Ousova, Zhanna Savitskaya, Hannah Levardon, Elise Maurat, Marilyne Campagnac, Thomas Trian and Patrick Berger
    Citation: Respiratory Research 2024 25:314
  26. Due to a special hemodynamic feature, pulmonary vascular disease in pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) has two stages: reversible and irreversible. So far, the m...

    Authors: Haowei Zeng, Beidi Lan, Bingyi Li, Hang Xie, Enfa Zhao, Xiaoqin Liu, Xiaoyi Xue, Jingyan Sun, Linjie Su and Yushun Zhang
    Citation: Respiratory Research 2024 25:313
  27. Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for C...

    Authors: Fleur–Stefanie L. I. M. van der Ven, Siebe G. Blok, Luciano C. Azevedo, Giacomo Bellani, Michela Botta, Elisa Estenssoro, Eddy Fan, Juliana Carvalho Ferreira, John G. Laffey, Ignacio Martin–Loeches, Ana Motos, Tai Pham, Oscar Peñuelas, Antonio Pesenti, Luigi Pisani, Ary Serpa Neto…
    Citation: Respiratory Research 2024 25:312

    The Correction to this article has been published in Respiratory Research 2025 26:117

  28. Tea polyphenols (TPs), prominent constituents of green tea, possess remarkable antioxidant and anti-inflammatory properties. However, their therapeutic potential is limited due to low absorption and poor bioav...

    Authors: Suidong Ouyang, Peishan Lu, Jianing Li, Hua Jin, Wanhua Wu, Renxing Luo, Bin Wang, Xueqin Huang, Xinlong Lian and Gonghua Huang
    Citation: Respiratory Research 2024 25:311
  29. Thermal ablation is a minimally invasive treatment for non-small cell lung cancer (NSCLC). Aside from causing an immediate direct tumour cell injury, the effects of thermal ablation on the internal microenviro...

    Authors: Xinglu Zhang, Shuai Shao, Nan Song, Baolu Yang, Fengjiao Liu, Zhaohui Tong, Feng Wang and Jieqiong Li
    Citation: Respiratory Research 2024 25:309
  30. Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstructi...

    Authors: Yen-Fu Chen, Hsin-Han Hou, Ning Chien, Kai-Zen Lu, Chieh-Hua Lin, Yu-Chieh Liao, Kuo-Lung Lor, Jung-Yien Chien, Chung-Ming Chen, Chung-Yu Chen, Shih-Lung Cheng, Hao-Chien Wang, Po-Ren Hsueh and Chong-Jen Yu
    Citation: Respiratory Research 2024 25:308
  31. Cigar use among adults in the United States has remained relatively stable in the past decade and occupies a growing part of the tobacco marketplace as cigarette use has declined. While studies have establishe...

    Authors: Akash Patel, James H. Buszkiewicz, Steven Cook, Douglas A. Arenberg and Nancy L. Fleischer
    Citation: Respiratory Research 2024 25:305
  32. Acute lung injury (ALI) following pneumonia involves uncontrolled inflammation and tissue injury, leading to high mortality. We previously confirmed the significantly increased cargo content and extracellular ...

    Authors: Yuna Bang, Sein Hwang, Young Eun Kim, Dong Kyung Sung, Misun Yang, So Yoon Ahn, Se In Sung, Kyeung Min Joo and Yun Sil Chang
    Citation: Respiratory Research 2024 25:303
  33. Chronic obstructive pulmonary disease(COPD) is a gradually worsening and fatal heterogeneous lung disease characterized by airflow limitation and increasingly decline in lung function. Currently, it is one of ...

    Authors: Kexin Liao, Fengshuo Wang, Chenhao Xia, Ze Xu, Sen Zhong, Wenqi Bi and Jingjing Ruan
    Citation: Respiratory Research 2024 25:302
  34. Previous research has revealed the potential impact of circadian rhythms on pulmonary diseases; however, the connection between circadian rhythm-associated Thyrotroph Embryonic Factor (TEF) and Pulmonary Arter...

    Authors: Dandan Chen, Qi Jin, Lifan Yang, Xiaochun Zhang, Mingfei Li, Lei Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge and Lihua Guan
    Citation: Respiratory Research 2024 25:301
  35. In recent years, the incorporation of LAMAs into asthma therapy has been expected to enhance symptom control. However, a significant number of patients with asthma continue to experience poorly managed symptom...

    Authors: Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama and Hirofumi Chiba
    Citation: Respiratory Research 2024 25:300
  36. Although recent studies provide mechanistic understanding to the pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive promise for treating this disease. Type II alveolar epit...

    Authors: Jiaojiao Zhu, Xingkun Ao, Yuhao Liu, Shenghui Zhou, Yifan Hou, Ziyan Yan, Lin Zhou, Huixi Chen, Ping Wang, Xinxin Liang, Dafei Xie, Shanshan Gao, Ping-Kun Zhou and Yongqing Gu
    Citation: Respiratory Research 2024 25:299
  37. Increasing functional residual capacity (FRC) or tidal volume (VT) reduces airway resistance and attenuates the response to bronchoconstrictor stimuli in animals and humans. What is unknown is which one of the ab...

    Authors: Alessandro Gobbi, Andrea Antonelli, Raffaele Dellaca, Giulia M. Pellegrino, Riccardo Pellegrino, Jeffrey J. Fredberg, Julian Solway and Vito Brusasco
    Citation: Respiratory Research 2024 25:298
  38. Japanese guidelines recommend triple inhaled corticosteroid (ICS)/long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) and n...

    Authors: Shigeo Muro, Tomotaka Kawayama, Hisatoshi Sugiura, Munehiro Seki, Elizabeth A. Duncan, Karin Bowen, Jonathan Marshall, Ayman Megally and Mehul Patel
    Citation: Respiratory Research 2024 25:297
  39. Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there is a paucity of studies that reflect the available biomarkers from separate gene expression profiles ...

    Authors: Chuang Yang, Yi-Hang Liu and Hai-Kuo Zheng
    Citation: Respiratory Research 2024 25:296
  40. Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium s...

    Authors: Elizabeth L. McDuffie, Reynold A. Panettieri Jr. and Charles P. Scott
    Citation: Respiratory Research 2024 25:295

    The Correction to this article has been published in Respiratory Research 2024 25:371

  41. Lianhuaqingwen (LHQW) has been used in the treatment of chronic bronchitis, but the precise mechanism through which LHQW exhibits its anti-inflammatory effects in this context is not yet fully understood. The ...

    Authors: Shaozhang Lin, Shuan Wang, Qingping Jiang, Shaoyan Liu, Shujing Liu and Tonghui Cai
    Citation: Respiratory Research 2024 25:294
  42. Pooled analyses of previous randomized controlled trials reported that antifibrotics improved survival in patients with idiopathic pulmonary fibrosis (IPF), but the results were only based on short-term outcom...

    Authors: Hironao Hozumi, Koichi Miyashita, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui and Takafumi Suda
    Citation: Respiratory Research 2024 25:293
  43. Malnutrition is common in patients with chronic cardiovascular disease and is associated with significantly higher all-cause mortality. Approximately one-third of patients with heart failure are malnourished. ...

    Authors: Sicheng Zhang, Sicong Li, Luyang Gao, Qing Zhao, Tao Yang, Qixian Zeng, Zhihua Huang, Xin Li, Anqi Duan, Yijia Wang, Zhihui Zhao, Qin Luo and Zhihong Liu
    Citation: Respiratory Research 2024 25:292
  44. Acute lung injury (ALI) is characterized by an unregulated inflammatory reaction, often leading to severe morbidity and ultimately death. Excessive inflammation caused by M1 macrophage polarization and pyropto...

    Authors: Guiyin Zhu, Haiyang Yu, Tian Peng, Kun Yang, Xue Xu and Wen Gu
    Citation: Respiratory Research 2024 25:291

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