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Fig. 4 | Respiratory Research

Fig. 4

From: Inhibition of DLK1 regulates AT2 differentiation and alleviates established pulmonary fibrosis by upregulating TTF-1/CLDN6

Fig. 4

Conditional knockdown of DLK1 caused less alveolar epithelial injury during fibrosis. A FCM analysis of the proportion of AT2 cells in control, AAV-NC, and AAV-siDLK1 treated SPC-EGFP mice. B-E CD24- Sca-1- AT2 cells were analyzed, Epcam + cells in total cells and the number of AT2 were calculated. F Representative fluorescence images of SPC (green) and DAPI (blue) were performed in the indicated group, the scale bar 50um. G, H FCM analysis of CD45 + and SPC-EGFP positive AT2 in BALF. I, J TUNEL staining was analyzed in control, AAV-NC, and AAV-siDLK1-treated BLM mice. K Western blot analysis of Bcl-2 and BAX in AAV-NC and AAV-siDLK1 treated BLM mice. Data are presented as mean ± SEM

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Respiratory Research

ISSN: 1465-993X

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