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Fig. 3 | Respiratory Research

Fig. 3

From: Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension

Fig. 3

IPAH classical and intermediate monocyte subpopulations show a deviated trajectory. (A) Trajectory analysis (black line) for Control and IPAH monocytes. White circled ”O”” represents the starting pseudotime, red circled “T” represent terminal endpoints, and black circled “B” represent branching of trajectory. Pseudotime color spectrum shows purple as the starting time, progressing to yellow as the endpoint. (B) UMAP of monocyte clusters configured for trajectory analysis showing subpopulation characterization markers: Classical monocytes, high CD14 expression; Intermediate monocytes, high HLA-DRA expression; non-classical monocytes, low CD14 and high FCGR3A expression. (C) UMAP of gene expression profile for: FOS, JUNB, DUSP1, PLP2, ANXA1, PPDPF, STAT1 and HLA-B. n = 6/ group

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Respiratory Research

ISSN: 1465-993X

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