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Fig. 5 | Respiratory Research

Fig. 5

From: Thioredoxin: a key factor in cold tumor formation and a promising biomarker for immunotherapy resistance in NSCLC

Fig. 5

TXN down-regulates CD40 expression in NSCLC cells. (A) Venn diagram of genes positively and negatively correlated with TXN expression in TCGA-LUAD and TCGA-LUSC datasets. (B) GO analysis of the intersection of positively and negatively correlated genes in TCGA-LUAD and TCGA-LUSC. (C) GeneMANIA network of TXN and CD40 interaction. (D) AlphaFold3 predicted TXN and CD40 interaction. (E) Correlation between TXN and CD40/CD40L expression in TCGA-LUAD and TCGA-LUSC datasets. (F) Flow cytometry analysis of CD40 expression in TXN-stably knocked down A549 and SK-MES-1 cells

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Respiratory Research

ISSN: 1465-993X

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