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Fig. 4 | Respiratory Research

Fig. 4

From: Thioredoxin: a key factor in cold tumor formation and a promising biomarker for immunotherapy resistance in NSCLC

Fig. 4

TXN Facilitates Proliferation and Migration while Inhibiting Immune-Mediated Killing in NSCLC. (A) TXN mRNA expression in TCGA-LUAD and TCGA-LUSC tumor and matched non-tumor tissues. (B) RT-qPCR analysis of TXN mRNA expression in 20 LUAD and LUSC tumor and matched non-tumor tissues. (C) Western blot analysis of TXN protein expression in LUAD and LUSC tumors and matched-non tissues. (D-E) Colony formation and CCK-8 assays assessing the impact of stable TXN knockdown on A549 and SK-MES-1 cell survival and proliferation (n = 3). (F) Cell migration assay showing the effect of stable TXN knockdown on A549 and SK-MES-1 migration. (G) Survival of tumor cells co-cultured with activated Jurkat cells, assessed by crystal violet staining

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Respiratory Research

ISSN: 1465-993X

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