Fig. 3

High TXN expression disrupts NSCLC immune surveillance. All data were based on scRNA-seq data from the study by Philip et al. [27]. (A) UMAP visualization of the scRNA-seq data. (B) Classification of samples into “TXN-high” and “TXN-low” groups based on TXN expression levels. (C) UMAP visualization of TXN expression in the “TXN-high” and “TXN-low” groups. (D) Relative proportion of immune cell subsets in the “TXN-high” and “TXN-low” groups. (E) CellChat analysis of signaling pathway intensity between the “TXN-high” and “TXN-low” groups. (F) Network centrality analysis of cell communication in the “TXN-high” and “TXN-low” groups. (G) Heatmap of overall cell-cell contact and secreted signaling communication intensity in the “TXN-high” and “TXN-low” groups. (H) Volcano plot showing differentially expressed genes between the “TXN-high” and “TXN-low” groups across various cell subpopulations. (I) GSVA analysis of differentially expressed pathways in the “TXN-high” and “TXN-low” groups