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Fig. 2 | Respiratory Research

Fig. 2

From: Thioredoxin: a key factor in cold tumor formation and a promising biomarker for immunotherapy resistance in NSCLC

Fig. 2

TXN is associated with a non-inflammatory tumor immune microenvironment in NSCLC. (A) Correlation between TXN expression and immune cell infiltration in TCGA-LUAD and TCGA-LUSC, assessed by ssGSEA. (B) Comparison of StromaScore, ImmuneScore, and ESTIMATE scores between TXN-High and TXN-Low subgroups, showing lower scores in the TXN-High group. (C) Comparison of cancer immune cycle activity between TXN-High and TXN-Low subgroups in TCGA-LUAD and TCGA-LUSC. (D) Correlation between TXN expression and tumor mutation burden (TMB) in TCGA-LUAD and TCGA-LUSC. (E) Correlation between TXN expression and damage-associated molecular patterns (DAMPs) in TCGA-LUAD and TCGA-LUSC. (F) Correlation between TXN expression and chemokines, receptors, and immunostimulatory molecules in TCGA-LUAD and TCGA-LUSC

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Respiratory Research

ISSN: 1465-993X

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