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Fig. 1 | Respiratory Research

Fig. 1

From: Thioredoxin: a key factor in cold tumor formation and a promising biomarker for immunotherapy resistance in NSCLC

Fig. 1

High TXN Expression in Epithelial Cells Correlates with PD-1 Antibody Resistance in NMPR NSCLC. (A) UMAP visualization of epithelial cells from MPR and NMPR patients based on scRNA-seq data from the GSE207422 dataset. (B) Volcano plot showing differentially expressed genes in epithelial cells from MPR and NMPR patients. (C) GSVA of differentially expressed pathways in these epithelial cells. (D) Venn diagram illustrating the overlap of differentially expressed UPR-related genes in MPR and NMPR patients. (E) TXN expression in epithelial cells from NSCLC, including LUAD and LUSC subtypes, in MPR and NMPR patients. (F) UMAP visualization of TXN expression across various cell types from MPR and NMPR patients based on scRNA-seq data. (G) Violin plot showing TXN expression in different cell types from MPR and NMPR NSCLC patients. (H) TXN expression in patients with non-response (NR) and response (R) to ICB treatment (left), and the diagnostic ROC curve for predicting treatment response (right)

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Respiratory Research

ISSN: 1465-993X

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