Fig. 1

Image processing steps: CT LVAS, CTVI_HU and CTVI_Jac are generated from an inhale/exhale breath-hold CT pair. CTVI_HU and CTVI_Jac are resampled to the voxel size and image dimensions of the PET image, masked to match the CT LVAS image, and a median filter of radius 3.5 voxels (7Â mm) applied. The Galligas PET image is masked to match the CT LVAS image and smoothed