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Fig. 4 | Respiratory Research

Fig. 4

From: Dysregulated metabolic pathways of pulmonary fibrosis and the lipids associated with the effects of nintedanib therapy

Fig. 4

(A) Enriched lipid pathways in the comparison between PF patients and HC subjects in Study 1. (B) Enriched pathway of glycerophospholipid metabolism. Pathways were generated using Metaboanalyst. Each number in the box denotes the KEGG ID of the lipid. Red boxes indicate lipids detected in the present study, and those lipids were listed in the dotted-line boxes. Red lipids indicate up-regulation in PF, whereas blue lipids indicate down-regulation in PF. (C) Metabolic pathways of LPC and LPE. 1,2-diacyl-sn-glycerol is converted to PC and PE. PC can be delivered from PE by phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase (PEMT). PC is catabolized to LPC by lecithin-cholesterol acyltransferase (LCAT) and phospholipase A2 (PLA2), and lysophosphatidylcholine acyltransferase (LPCAT) synthesizes PC from LPC. PE is catabolized to LPE by PLA2, and lysophosphatidylethanolamine acyltransferase (LPEAT) synthesizes PE from LPE. LPC and LPE are converted to LPA by autotaxin (ATX)

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Respiratory Research

ISSN: 1465-993X

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