Fig. 7

Identification and characterization of the subpopulation with high Ccl17 expression among monocytes and macrophages. (A, B) UMAP and density plots describing the distribution of Ccl17 expressing cells in monocytes and macrophages. Interstitial macrophages show high mRNA expression levels of Ccl17. (C, D) UMAP and density plots describing the distribution of Ccl17 expressing cells in interstitial macrophages. Cluster 5 shows high mRNA expression levels of Ccl17. (E) Violin plots of Ccl17 and representative genes co-expressed with Ccl17 in cluster 5. (F) The 15 most significantly (P < 0.05) enriched terms in Gene Ontology biological process in the 100 most significantly co-expressed genes with Ccl17 in cluster 5. This analysis was performed using a string database. (G) Changes in the number of cells in cluster 5. n = 5 mice per group. The numbers were compared by analysis of variance (ANOVA), and Dunnett’s method was applied to adjust for the ANOVA P values. *P < 0.05; **P < 0.01. Ccl, C-C motif chemokine ligand; Asgr, asialoglycoprotein receptor; Slc27a3, solute carrier family 27 member 3