Table 5 Correlations between study measures and diurnal cortisol slope
| Â | Ln- Diurnal slope | |||
|---|---|---|---|---|
Baseline (n = 20) | End of week 1 (n = 17) | End of week 3 (n = 11) | At least 3 months on the blinded extension study (n = 7) | |
Worst (NRS) | r = 0.33 p = 0.15 | r = 0.27 p = 0.29 | r = 0.33 p = 0.36 | r = 0.79 p = 0.11 |
Average (NRS) | rs = 0.30 p = 0.21 | rs = 0.31 p = 0.23 | r = 0.08 p = 0.82 | r = 0.89 p = 0.04 |
Distress (NRS) | r=-0.01 p = 0.98 | r = 0.02 p = 0.93 | r=-0.37 p = 0.29 | r = 0.10 p = 0.87 |
mMRC | rs=-0.18 p = 0.45 | rs=-0.45 p = 0.07 | rs=-0.56 p = 0.08 | - |
AKPS | rs=-0.66 p = 0.001 | rs=-0.12 p = 0.66 | rs=-0.24 p = 0.49 | rs = 0.00 p = 1.00 |
QOL (EQ-5D-5 L VAS) | r = 0.14 p = 0.56 | r=-0.14 p = 0.59 | - | rs=-0.62 p = 0.27 |
Subjective sleep quality | rs=-0.61 p = 0.005 | rs=-0.42 p = 0.10 | rs=-0.29 p = 0.43 | rs = 0.58 p = 0.31 |
HADS– anxiety | r=-0.15 p = 0.54 | r = 0.04 p = 0.89 | - | - |
HADS– depression | r = 0.09 p = 0.73 | r=-0.50 p = 0.04 | - | - |
Global impression of change | - | rs = 0.03 p = 0.91 | rs = 0.10 p = 0.78 | rs = 0.98 p = 0.01 |