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Table 2 Logistic regression analysis for factors related to PPCs in the entire cohort and never-smokers

From: The association and impact of radiographic, pathological emphysema and spirometric airway obstruction on patients with resectable lung adenocarcinoma

Characteristics

The entire cohort

Never-smokers

Univariate analysis

P value

Multivariate analysis

P value*

Univariable analysis

P value

Multivariate analysis

P value#

Age, year

1.00(0.98–1.03)

0.572

  

0.99(0.96–1.02)

0.469

  

Sex, male

1.92(1.24–2.98)

0.004

1.40(0.82–2.37)

0.213

1.59(0.89–2.84)

0.120

  

BMI, kg/m2

0.99(0.92–1.05)

0.661

  

1.02(0.94–1.12)

0.646

  

Smoking history

        

 Never smoker

Reference

   

-

-

  

 Former or current smoker

1.60(1.02–2.50)

0.040

1.07(0.63–1.80)

0.804

-

-

  

CT-defined emphysema

        

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

2.87(1.79–4.59)

< 0.001

2.33 (1.38–3.91)

0.001

2.76(1.40–5.45)

0.003

2.75(1.39–5.44)

0.004

Airway obstruction

        

 No

Reference

   

Reference

   

 Yes

1.16(0.67–1.99)

0.596

  

0.89(0.39–2.05)

0.792

  

Surgical approach

        

 VATS

Reference

 

Reference

 

Reference

 

Reference

 

 Thoracotomy

2.37(1.31–4.29)

0.005

2.12 (1.16–3.91)

0.015

1.99(0.89–4.74)

0.095

1.98(0.87–4.47)

0.103

Extent of resection

        

 Wedge resection

Reference

   

Reference

   

 Segmentectomy

-

0.999

  

-

0.999

  

 Lobectomy

0.88(0.41–1.91)

0.754

  

1.04(0.36–3.02)

0.943

  

 Pneumonectomy

1.60(0.17–15.48)

0.685

  

-

0.999

  
  1. Abbreviations: PPCs = postoperative pulmonary complications; CT = computed tomography; LAA = low-attenuation areas; OR = odds ratio; CI = confidence interval; BMI = body mass index; VATS = video-assisted thoracoscopic surgery
  2. *False discovery rate corrected P values in the entire cohort were as follows: sex, P = 0.284; smoking history, P = 0.804; CT-defined emphysema, P = 0.004; and surgical approach, P = 0.030
  3. #False discovery rate corrected P values in never-smokers were as follows: CT-defined emphysema P = 0.008; and surgical approach, P = 0.103
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Respiratory Research

ISSN: 1465-993X

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