Fig. 6

Epexo lncRNAs as a Classifier for Discrimination of Pathological Types and M Staging. (a) Depiction of the expression profiles of six selected lncRNAs in plasma-derived Epexo from patients diagnosed with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). (b)Accuracy, represented as AUC, of the six selected lncRNAs and all possible combinations in distinguishing between LUAD and LUSC patients. (*P<0.05, **P<0.01, and ***P<0.001). (c)Comparative analysis of model diagnostic outcomes and actual outcomes using two classifiers: one comprising SP2-AS1 and ZNRF3-AS1, and the other comprising linc01125, HNF1A-AS1, and SP2-AS1. (d)Scatter plot displaying the distribution consistency between model diagnosis and actual diagnosis. Blue triangles and red circles represent true LUAD and LUSC, indicating correct diagnostic outcomes by the model, while red triangles and blue circles represent false LUAD and LUSC, implying erroneous diagnostic outcomes by the model. (e)Expression patterns of the six selected lncRNAs in plasma-derived Epexo among patients with positive (M0) and negative (M1) distant metastasis. P value was obtained using unpaired t-tests with Welch's correction.