Fig. 4

Assessment of diagnostic efficacy using selected lncRNAs and their combinations on NSCLC. (a) Area under the Receiver Operating Characteristics (ROC) curve (AUC) values for six selected lncRNAs and all possible combinations in distinguishing NSCLC patients from healthy controls. The optimal diagnostic combination, identified based on maximizing the AUC values, is highlighted in red. (b) Individual ROC curves for each lncRNA. (c-d) ROC curve (c) and precision-recall curve (d) for the best diagnostic combination. (e) Subgroup ROC curves for the most effective diagnostic combination in differentiating patients with local stage (LS) or regional or distant stage (RDS) from healthy controls. (f-j) Scatter plots illustrating the correlation between the results of repeated measurements of linc01125 (f), linc01160 (g), HNF1A-AS1 (h), MIR100HG (i), and ZNRF3-AS1. (j) Expression levels in plasma-derived Epexo from 31 NSCLC patients. Spearman rank correlation test was used to calculate the correlation coefficient (r) and P value. (k) Comparative analysis of model diagnostic outcomes from two sets of repeated testing in 31 NSCLC patients