Fig. 2

Assessment of dehydrocorydaline toxicity in mice. A Results of liquid chromatography tandem mass spectrometry (LC–MS/MS) analysis of DHC content in lung tissue of Control group (n = 4), BLM + L-DHC group (n = 4) and BLM + H + DHC group (n = 6) mice. The results are expressed as the weight of DHC (in nanograms) per gram of mouse lung tissue. L-DHC: 5 mg/kg DHC. H-DHC: 10 mg/kg DHC. B–F Alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), urea (UREA), and creatinine (Cr) levels in mouse serum across each group. The statistical data reflect findings from 6 mice in each group, presented as mean ± SD. G Hepatobiliary, splenic, renal, heart, and intestine sections stained with H&E for the PBS + H-DHC and the PBS + DMSO (Control) groups. ***p < 0.001