Fig. 4

WNT5A levels associated with overall survival, disease stage and therapy response. A: Kaplan–Meier O/S distributions stratified by supernatant WNT5A level (cut-off: 740 pg/mL) (p = 0.0042, from log-rank test). B: Kaplan–Meier O/S distributions stratified by exosome surface + cargo WNT5A level (cut-off: 2.5 × 10^− 9 pg WNT5A/ NP) (p = 0.028, from log-rank test). WNT5A on the surface of exosomes is elevated in the LUSC subtype and associated with distant metastasis (C), Univariate Cox regression analysis (D) Multivariate Cox regression analysis (E), positive lymph node status (F) and lack of response to therapy (G). D: ROC analysis was performed to calculate sensitivities and specificities for differentiation between LUAD and LUSC metastatic patients. AUC represents the diagnostic capacity. H: WNT5A transported on the exosome surface is a suitable marker in distinguishing LUAD patients with PD from LUSC patients with a lack of therapy response. (PR, partial response; PD, progressive disease; SD, stable disease)