The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis

Table 4 Studies included in the meta-analysis

No	Age group	n	Age, years	Diagnosis	Revisiting the number of patients with mutations in BMPR2		Country	Refs.
No	Age group	n	Age, years	Diagnosis	Before	After	Country	Refs.
1	Adults	69	50 ± 20	IPAH	5	3	Taiwan	[16]
2	Adults	45	46 ± 15	IPAH + HPAH	8	7	Taiwan	[17]
3	Adults	201	47 ± 17	IPAH	20	18	Germany	[18]
4	Adults and children	46	29.5 ± 7	IPAH	4	2	Saudi Arabia	[1]
5	Adults	126	49 ± 16	IPAH	29	27	Netherlands	[19]
6	Adults and children	331	28 ± 11	IPAH	81	66	China	[20]
7	Adults	191	30.7 ± 10.6	IPAH	37	34	China	[21]
8	Adults	13	33	IPAH	1	1	Lebanon	[22]
9	Adults	127	42.84 ± 15,22	IPAH	24	13	Spain	[23]
10	Adults	81	39.0 ± 13.4	IPAH + HPAH	14	11	USA	[24]
11	Adults	28	49 ± 16	IPAH	7	3	Spain	[25]
12	Adults	275	40 ± 15	IPAH + HPAH	82	57	China	[26]
13	Adults and children	106	11.1 ± 10.6	IPAH + HPAH	28	19	China	[27]
14	Adults	73	42.7 ± 19.8	IPAH	16	14	Korea	[28]
15	Adults	82		IPAH	15	27	Netherlands	[29]
16	Adults	8	42 ± 9	IPAH	1	1	Turkey	[30]
17	Adults	217		IPAH + HPAH	45	37	China	[31]
18	Adults	37	50 ± 13	IPAH + HPAH + PAH-CHD + PVOD + PAH-HHT	15	9	Germany	[32]
19	Adults	43		IPAH	6	6	Japan	[33]
20	Adults and children	40	30.4 (6–59)	IPAH	14	14	Japan	[34]
21	Adults and children	516		IPAH + HPAH	151	114	France	[35]
22	Adults	117		IPAH + HPAH	37	34	Japan	[36]
23	Adults and children	44	28.5 ± 11.5	IPAH + HPAH	23	19	France	[3]
24	Adults and children	203		IPAH	31	27	France	[37]
25	Adults	105	56.9 ± 14.47	IPAH + HPAH	NA	11	Russia	Own data

ISSN: 1465-993X