Fig. 6

The molecular signatures induced by menthol flavored JUUL aerosol exposures are reduced in the lungs of MMP12 deficient mice. Heatmaps displaying a, b global transcriptomic responses resulting from exposures to menthol-flavored JUUL aerosols + PBS in WT and MMP12 KO mice compared to respective air controls. Data obtained through bulk RNA sequencing and are expressed as Log2 fold-changes > ± 1.5 with a p-value < 0.05 for n = 4 mice per group. Red denotes up-regulation and green denotes down-regulation