Evaluation of the influenza vaccine protection in the house dust mite-induced chronic allergic asthma mice model and the evaluation of squalene oil in water emulsion as an adjuvant candidate

Table 2 Lung inflammation scoring of mice after influenza infection

Score	Bronchiolar Infiltrate		Alveolar involvement
Score	Intraluminal infiltrate	Peri bronchial Infiltrate	Alveolar involvement
0	None	None	None
1	≦25% of visualized lumens; inflammatory cell exudates and predominate mononuclear	Infiltrate ≦4 cells thick	Slight increase of cellularity
2	25–50% of visualized lumens; inflammatory cell exudates and mixed mono- and polymorphonuclear	Infiltrate 5–10 cells thick	Moderate increase of cellularity
3	50–75% of visualized lumens; inflammatory cell exudates and predominately polymorphonuclear	25–50% of visualized lumens	Significant increase of cellularity, thickening; obliteration of < 50% of visualized alveolar space
4	Diffuse; inflammatory cell exudates and predominately polymorphonuclear	Diffuse	Obliteration of > 50% of the alveolar space

ISSN: 1465-993X