Table 1 Main clinical characteristics of the enrolled patients

Age

57.2 (13.3)

57.4 (13.3)

59.6 (12.6)

0.464

51.7 (13.6)

0.127

0.023

Gender (m)

50 (47.6%)

11 (35.5%)

24 (47.1%)

0.425

15 (65.2%)

0.059

0.232

Previous comorbidities

 Cardiovascular

36 (32.8%)

7 (22.6%)

25 (49.0%)

0.032

4 (12.9%)

1

0.001

 Autoimmune

15 (23.4%)

3 (12.5%)

9 (22.5%)

0.483

3 (37.5%)

0.203

0.51

 Connective tissue disease

3 (4.7%)

1 (4.17%)

2 (5.13%)

1

0 (0.00%)

1

1

 Obesity

17 (25.4%)

5 (20.8%)

9 (23.1%)

1

3 (33.3%)

0.822

0.974

DLCO 12 m

78.9 (14.5)

91.1 (10.1)

68.4 (9.53)

< 0.001

89.1 (7.04)

0.637

< 0.001

PS 12 m, n (%)

51 (52.0%)

0 (0.00%)

51 (100%)

< 0.001

0 (0.00%)

< 0.001

DLCO 6 m

80.4 (17.4)

92.8 (15.8)

71.7 (12.5)

< 0.001

82.2 (19.5)

0.164

0.152

PS 6 m, n (%)

40 (46.5%)

4 (12.9%)

33 (71.7%)

< 0.001

3 (33.3%)

0.316

0.051

Non-pulmonary symptoms 12 m

60 (53.1%)

0 (0.00%)

29 (56.9%)

< 0.001

31 (100%)

< 0.001

< 0.001

Non-pulmonary symptoms 6 m

74 (64.9%)

14 (44.0%)

52 (71.4%)

0.033

31 (100%)

0.001

0.03

ICU admission, n (%)

42 (39.3%)

13 (41.9%)

25 (49.0%)

0.693

4 (16.0%)

0.071

0.011

Corticoids during acute episode

37 (57.8%)

12 (54.5%)

23 (63.9%)

0.668

2 (33.3%)

0.648

0.202

Severity (WHO)

0.386

< 0.001

< 0.001

 1

27 (23.9%)

1 (3.23%)

6 (11.8%)

20 (64.5%)

 2

1 (0.88%)

0 (0.00%)

1 (1.96%)

0 (0.00%)

 3

20 (17.7%)

8 (25.8%)

9 (17.6%)

3 (9.68%)

 4

17 (15.0%)

5 (16.1%)

8 (15.7%)

4 (12.9%)

 5

21 (18.6%)

8 (25.8%)

10 (19.6%)

3 (9.68%)

 6

8 (7.08%)

1 (3.23%)

7 (13.7%)

0 (0.00%)

 7

11 (9.73%)

3 (9.68%)

7 (13.7%)

1 (3.23%)