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Table 2 Markers commonly expressed in transcriptome and proteome analysis of PCLS

From: Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury

 

Transcriptomics

Proteomics

 

Gene

Description

Log fold change

FDR

Log fold change

FDR

1

HMOX1

Heme oxygenase 1

5.49

1.12E−270

3.73

2.77E−06

2

CXCL8

Interleukin-8

4.47

7.42E−141

3.86

2.81E−05

3

IL6

Interleukin-6

4.01

4.91E−26

2.69

0.001

4

IL1B

Interleukin-1 beta

3.75

3.82E−27

3.04

0.001

5

GBP5

Guanylate-binding protein 5

3.62

2.71E−26

1.57

0.004

6

IDO1

Indoleamine 2,3-dioxygenase 1

3.50

7.12E−14

2.61

0.003

7

HSPA6

Heat shock protein family A Member 6

3.37

2.30E−116

1.76

0.014

8

CXCL1

Chemokine (C-X-C motif) ligand 1

3.13

4.23E−29

3.43

0.001

9

PTGS2

Prostaglandin G synthase 2

3.09

2.67E−119

2.39

0.002

10

CXCL2

Chemokine (C-X-C motif) ligand 2

3.04

2.95E−55

3.44

9.25E−05

11

TNFAIP6

Tumour necrosis factor-inducible gene 6 protein

2.89

6.87E−18

2.65

0.001

12

GBP4

Guanylate-binding protein 4

2.87

1.09E−18

1.14

0.010

13

CFB

Complement factor B

2.70

4.94E−61

1.06

0.015

14

CXCL5

Chemokine (C-X-C motif) ligand 5

2.44

3.25E−19

2.26

0.001

15

FTH1

Ferritin heavy chain

2.11

2.10E−64

1.82

2.56E−05

16

CCL3

Chemokine (C–C motif) ligand 3

2.10

1.06E−06

2.13

0.005

17

ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4

2.08

1.58E−22

1.04

0.013

18

MX1

MX Dynamin Like GTPase 1

2.07

2.71E−28

1.05

0.003

19

APOL1

Apolipoprotein L1

1.78

3.34E−37

1.45

0.002

20

CEMIP

Cell migration-inducing and hyaluronan-binding protein

1.67

1.62E−16

1.08

0.017

21

SRGN

Serglycin

1.65

2.16E−27

1.36

0.007

22

GDF15

Growth differentiation factor 15

1.55

8.89E−24

1.42

0.003

23

MMP1

Matrix Metallopeptidase 1

1.53

2.85E−20

1.82

0.001

24

C1S

Complement C1s subcomponent

1.34

3.88E−31

1.11

0.001

25

GBP3

Guanylate-binding protein 3

1.33

1.86E−11

1.06

0.011

26

FOSL2

Fos-related antigen 2

1.11

1.32E−15

1.03

0.001

27

FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A

-2.05

5.14E−24

-1.20

0.006

  1. FDR false discovery rate
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Respiratory Research

ISSN: 1465-993X

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