Fig. 2
From: Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury
Transcriptomic profiles in heme and control PCLS. a Volcano plot of overall DEG between the heme-stimulated group and the control group. A total of 1827 genes were selected following log2 FC > 1 and adj p-value < 0.05. b Clustered heatmap of 10 genes associated with inflammatory pathway and ECM. c Gene ontology overrepresentation analysis (GO ORA) of biological processes (BP), molecular functions (MF) or cellular components (CC) in heme-stimulated group compared to control (adj p-value < 0.05) and horizontal axis corresponds to the negative log (base 10) of the p values. d Dot plot of activated and supressed pathways in gene set enrichment analysis (GSEA) using KEGG database in the heme-stimulated group as compared to control group (adj p-value < 0.05). The x-axis represents the number of genes in the core enrichment set divided by the total number of genes in the set. The size of the dots represents the size of the core enrichment set