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Fig. 8 | Respiratory Research

Fig. 8

From: Molecular mechanisms and therapeutic targets of acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection

Fig. 8

Validation and Functional Analysis of Key Proteins of AECOPD with P. aeruginosa Infection. (A) MCC analysis using Cytoscape, identifying key protein clusters. (B) MCODE analysis highlighting densely interconnected proteins. (C) Venn diagram showing intersection of MCC, MCODE, Balf-proteome, Plasma-proteome and WGCNA analyses, identifying three key proteins. (D) GO enrichment analysis of the three key proteins, highlighting immune response and oxidative stress-related processes. (E) KEGG pathway analysis showing enrichment in vesicle lumen an NET formation pathway. (F-K0 Box plots and ROC curves for AZU1, MPO, and RETN, confirming their differential expression and diagnostic value. *, P < 0.05. **, P < 0.01.***, P < 0.001

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Respiratory Research

ISSN: 1465-993X

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