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Fig. 6 | Respiratory Research

Fig. 6

From: Molecular mechanisms and therapeutic targets of acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection

Fig. 6

Plasma proteomics and peripheral blood transcriptomics analyses in AECOPD with P. aeruginosa infection. (A) Plasma proteomics identified 25 upregulated and 15 downregulated proteins. (B) GO analysis showed enrichment in inflammatory responses and neutrophil-mediated immunity. Azurophil granules and lysosomes were enriched in cellular component analysis. Molecular function and KEGG analysis highlighted serine-type endopeptidase activity and NET formation. (C) Transcriptomics identified 821 upregulated and 422 downregulated genes. (D) Enrichment analyses indicated pathways related to leukocyte migration, neutrophil chemotaxis, and macrophage activation. (E) Immune infiltration analysis revealed increases in neutrophils and macrophages. (F) The correlation matrix showed interactions between immune cell types. (G) Six overlapping biomarkers were identified. (H-I) GO and KEGG analysis highlighted antimicrobial responses and NET formation. *, P < 0.05. **, P < 0.01.***, P < 0.001

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Respiratory Research

ISSN: 1465-993X

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