Fig. 1

Multi-Omics Analysis for AECOPD with P. aeruginosa infection. This study utilizes a two-stage design comprising an initial discovery cohort, which is subsequently validated in a separate cohort. We conducted proteomic analyses of bronchoalveolar lavage fluid and plasma samples, alongside transcriptomic profiling of peripheral blood samples. These analyses were followed by comprehensive bioinformatics investigations aimed at elucidating the underlying mechanisms and identifying biomarkers associated with -induced acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection