Table 3 COPD and depression/anxiety
Outcome | No of outcome events/individuals | Unadjusted | Adjusted | |
|---|---|---|---|---|
N | HR (95% CI) | HR (95% CI) | Additive interaction (95% CI) | |
Cardiovascular disease | ||||
Atrial fibrillation | 453 280/5 464 764 | |||
No COPD or depression/anxiety | Reference | Reference | <-0.01 (-0.04, 0.04) | |
Depression/anxiety | 0.97 (0.96, 0.97) | 1.04 (1.03, 1.05) | ||
COPD | 1.68 (1.65, 1.70) | 1.63 (1.61, 1.65) | ||
COPD and depression/anxiety | 1.57 (1.55, 1.60) | 1.67 (1.64, 1.70) | ||
Cerebrovascular disease | 356 848/5 481 249 | |||
No COPD or depression/anxiety | Reference | Reference | 0.09 (0.05, 0.13) | |
Depression/anxiety | 1.28 (1.27, 1.29) | 1.37 (1.36, 1.38) | ||
COPD | 1.39 (1.37, 1.41) | 1.35 (1.33, 1.37) | ||
COPD and depression/anxiety | 1.73 (1.70, 1.76) | 1.81 (1.77, 1.84) | ||
Chronic heart failure | 383 601/5 515 858 | |||
No COPD or depression/anxiety | Reference | Reference | 0.40 (0.34, 0.45) | |
Depression/anxiety | 1.21 (1.20, 1.22) | 1.31 (1.30, 1.32) | ||
COPD | 2.87 (2.83, 2.90) | 2.74 (2.71, 2.78) | ||
COPD and depression/anxiety | 3.29 (3.25, 3.34) | 3.45 (3.40, 3.50) | ||
Ischemic heart disease | 429 938/5 355 693 | |||
No COPD or depression/anxiety | Reference | Reference | 0.16 (0.12, 0.20) | |
Depression/anxiety | 1.08 (1.07, 1.08) | 1.20 (1.19, 1.21) | ||
COPD | 1.79 (1.77, 1.82) | 1.73 (1.71, 1.76) | ||
COPD and depression/anxiety | 1.91 (1.88, 1.95) | 2.09 (2.06, 2.13) | ||
Peripheral arterial disease | 176 588/5 569 229 | |||
No COPD or depression/anxiety | Reference | Reference | 0.16 (0.08, 0.24) | |
Depression/anxiety | 1.21 (1.19, 1.22) | 1.33 (1.31, 1.34) | ||
COPD | 2.60 (2.56, 2.65) | 2.49 (2.44, 2.53) | ||
COPD and depression/anxiety | 2.78 (2.72, 2.85) | 2.98 (2.91, 3.05) | ||
Mortality | ||||
All-cause mortality | 1 078 751/5 624 306 | |||
No COPD or depression/anxiety | Reference | Reference | 0.59 (0.55, 0.63) | |
Depression/anxiety | 2.22 (2.21, 2.23) | 2.39 (2.38, 2.40) | ||
COPD | 2.86 (2.83, 2.88) | 2.74 (2.72, 2.76) | ||
COPD and depression/anxiety | 4.53 (4.49, 4.56) | 4.72 (4.68, 4.75) | ||
Cardiovascular death | 655 441/5 624 306 | |||
No COPD or depression/anxiety | Reference | Reference | 0.73 (0.68, 0.78) | |
Depression/anxiety | 2.11 (2.09, 2.12) | 2.28 (2.27, 2.29) | ||
COPD | 2.90 (2.87, 2.93) | 2.77 (2.74, 2.79) | ||
COPD and depression/anxiety | 4.56 (4.52, 4.60) | 4.77 (4.73, 4.82) | ||
Respiratory death | 252 179/5 624 306 | |||
No COPD or depression/anxiety | Reference | Reference | 5.68 (5.50, 5.85) | |
Depression/anxiety | 2.43 (2.41, 2.46) | 2.66 (2.63, 2.68) | ||
COPD | 9.24 (9.14, 9.35) | 8.78 (8.68, 8.88) | ||
COPD and depression/anxiety | 15.34 (15.17, 15.52) | 16.11 (15.93, 16.30) | ||