Table 3 Univariant analysis

Lung cancer characteristics

Lymph node staging, N (%):

N1

24 (8.48%)

17 (22.7%)

Ref.

Ref.

N2

106 (37.5%)

45 (60.0%)

0.60 [0.29;1.24]

0.167

N3

153 (54.1%)

13 (17.3%)

0.12 [0.05;0.28]

< 0.001

Anatomical Area, N (%):

Mediastinal

112 (39.6%)

39 (52.0%)

Ref.

Ref.

Hilar

107 (37.8%)

23 (30.7%)

0.62 [0.34;1.10]

0.103

Subcarinal

64 (22.6%)

13 (17.3%)

0.59 [0.28;1.16]

0.129

Histology, N (%):

Adenocarcinoma

138 (48.8%)

46 (61.3%)

Ref.

Ref.

Squamous cell carcinoma

110 (38.9%)

15 (20.0%)

0.41 [0.21;0.76]

0.004

Non-small-cell lung carcinoma not otherwise specified

35 (12.4%)

14 (18.7%)

1.20 [0.58;2.41]

0.609

EBUS characteristics

Diameter short axis, mm (SD)

8.33 (2.89)

11.6 (4.60)

1.26 [1.17;1.36]

< 0.001

Shape, N (%):

Oval

115 (40.9%)

22 (29.7%)

Ref.

Ref.

Round

96 (34.2%)

42 (56.8%)

2.27 [1.28;4.14]

0.005

Elongated

45 (16.0%)

5 (6.76%)

0.59 [0.19;1.57]

0.309

Triangular

19 (6.76%)

1 (1.35%)

0.31 [0.01;1.64]

0.201

Irregular

6 (2.14%)

4 (5.41%)

3.48 [0.80;13.6]

0.093

Margin, N (%):

Indistinct

33 (11.8%)

2 (2.70%)

Ref.

Ref.

Distinct

246 (88.2%)

72 (97.3%)

4.50 [1.32;30.5]

0.013

Heterogenicity, N (%):

No

172 (61.0%)

33 (44.6%)

Ref.

Ref.

Yes

110 (39.0%)

41 (55.4%)

1.94 [1.16;3.27]

0.012

Central hilar structure, N (%):

Absent

186 (66.7%)

65 (86.7%)

Ref.

Ref.

Present

93 (33.3%)

10 (13.3%)

0.31 [0.14;0.61]

< 0.001

PET/CT characteristics

Time between PET-EBUS, Mean (standard deviation)

28.1 (14.7)

24.1 (15.1)

0.98 [0.96;1.00]

0.036

SUVmax, Mean (standard deviation [SD])

12.9 (7.48)

10.1 (5.17)

0.94 [0.90;0.98]

0.003

SUVpeak, Mean (SD)

10.3 (6.29)

7.82 (4.48)

0.93 [0.88;0.97]

0.002

SUVmean, Mean (SD)

7.78 (4.72)

6.19 (3.65)

0.92 [0.86;0.98]

0.008

MTV, Mean (SD)

232 (441)

125 (253)

1.00 [1.00;1.00]

0.061

SUVmax vascular, Mean (SD)

640 (5103)

15.5 (22.8)

0.99 [0.98;1.00]

0.035

SUVmax liver, Median [Q1; Q3]

2.20 [1.89;2.50]

2.30 [1.95;2.60]

1.71 [1.00;2.93]

0.052

SUVmax, Median [Q1; Q3]

2.30 [1.90;3.10]

5.50 [3.35;8.75]

2.06 [1.71;2.47]

< 0.001

SUVpeak, Median [Q1; Q3]

1.90 [1.50;2.31]

4.10 [2.30;7.10]

2.81 [2.13;3.72]

< 0.001

SUVmean, Median [Q1; Q3]

1.58 [1.30;1.90]

3.30 [2.10;5.10]

3.44 [2.47;4.79]

< 0.001

SUVmax lymph node/primary lung mass index, Median [Q1; Q3]

0.20 [0.13;0.32]

0.57 [0.32;0.99]

1.85 [1.39;2.46]

< 0.001

SUVmax lymph node/vascular index, Median [Q1; Q3]

1.07 [0.89;1.47]

2.55 [1.56;4.14]

3.20 [2.37;4.32]

< 0.001

SUVmax lymph node/liver index, Median [Q1; Q3]

0.80 [0.63;1.14]

1.83 [1.14;3.10]

5.09 [3.30;7.86]

< 0.001

SUVpeak lymph node/primary lung mass index, Median [Q1; Q3]

0.20 [0.13;0.33]

0.65 [0.31;1.18]

2.05 [1.50;2.82]

< 0.001

SUVmean lymph node/primary lung mass index, Mean (SD)

0.45 (0.73)

0.97 (1.03)

1.84 [1.37;2.45]

< 0.001