Fig. 5

BRD4 inhibition decreased BRD4 and H3K27ac occupancy on promoter regions in vitro. a Venn diagram showing BRD4 and H3K27ac overlapped binding peaks in M0 and M2 AMs. b Genome-wide distribution of BRD4 and H3k27ac in AMs from M0 group, M2 group, ARV-825 + M2 group. c Heatmaps of BRD4 and H3k27ac occupancy on the promoter region (TSS ± 5 kb), aligned by the degree of BRD4 and H3k27ac signal intensity in AMs from M0 group, M2 group, ARV-825 + M2 group. d Binding intensity of BRD4 and H3k27ac across the gene body of the whole genome in AMs from M0 group, M2 group, ARV-825 + M2 group