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Table 3 Significant up- and down-regulated miRNAs in GACRS. Mean counts: normalized mean counts in the reference group. Log2 FC: base-2-fold change from infrequent to frequent exacerbators. Odds ratio: computed with logistic regression. 95% CI: 95% confidence interval for odds ratio. P-value: for differential expression between above and below-threshold groups, computed with DESeq2. FDR: false discovery rate adjusted p-values, with FDR < 0.10 considered significant

From: Peripheral blood miRNAs are associated with airflow below threshold in children with asthma

miR

Mean Counts

log2 FC

Odds Ratio

95% CI

p-value

FDR

hsa-let-7e-5p

92.7

0.426

0.75

(0.64 – 0.87)

0.0001

0.054

hsa-miR-342-3p

9580

-0.201

1.15

(1.07–1.23)

0.0002

0.054