Peripheral blood miRNAs are associated with airflow below threshold in children with asthma

Respiratory Research

Table 1 Baseline epidemiologic and clinical characteristics of the GACRS

	Below threshold (N = 220)	Above threshold (N = 141)	p-value
Gender
Male	92 (41.8%)	57 (40.4%)	0.879
Female	128 (58.2%)	84 (59.6%)
Age (years)
Mean (SD)	9.23 (1.76)	8.96 (1.98)	0.194
Median [Min, Max]	8.88 [6.12, 13.3]	8.90 [6.271, 12.9]
Height (cm)
Mean (SD)	133 (11.2)	132 (12.5)	0.53
Median [Min, Max]	131 [109, 167]	131 [103, 163]
Weight (kg)
Mean (SD)	33.1 (11.8)	31.9 (11.4)	0.356
Median [Min, Max]	30.9 [18.0, 81.6]	28.9 [15.0, 66.5]
BMI
Mean (SD)	18.3 (4.06)	17.8 (3.73)	0.27
Median [Min, Max]	17.5 [11.3, 41.4]	16.6 [12.5, 29.4]
% predicted Pre-BD FEV1
Mean (SD)	96.7 (15.3)	104 (16.2)	< 0.001
Median [Min, Max]	95.9 [46.2, 146]	102 [56.5, 180]
% predicted Post-BD FEV1
Mean (SD)	102 (14.2)	107 (15.7)	0.00186
Median [Min, Max]	101 [51.2, 152]	106 [57.3, 163]
% predicted Pre-BD FVC
Mean (SD)	105 (14.8)	98.7 (16.0)	< 0.001
Median [Min, Max]	104 [63.2, 162]	98.2 [52.5, 174]
% predicted Post-BD FVC
Mean (SD)	106 (14.2)	101 (16.1)	0.00434
Median [Min, Max]	105 [70.8, 167]	100 [53.1, 157]
% predicted FEV1/FVC Post-BD
Mean (SD)	96.5 (6.25)	106 (4.54)	< 0.001
Median [Min, Max]	97.4 [73.5, 113]	106 [92.5, 114]
FEV1/FVC Post-BD
Mean (SD)	85.8 (5.76)	94.4 (4.04)	< 0.001
Median [Min, Max]	86.6 [66.4, 99.9]	94.2 [83.6, 100]
FEV1/FVC Pre-BD
Mean (SD)	82.1 (6.11)	94.0 (3.67)	< 0.001
Median [Min, Max]	83.4 [61.8, 90.5]	93.4 [87.8, 100]
BD Response as % of baseline FEV1
Mean (SD)	6.39 (9.63)	3.37 (7.78)	0.00119
Median [Min, Max]	4.41 [-11.8, 48.6]	1.95 [-16.3, 35.3]
Inhaled Steroids
No	103 (46.8%)	62 (44.0%)	0.673
Yes	117 (53.2%)	79 (56.0%)

% predicted Pre-BD FEV1: Percent predicted pre-Bronchodilator Forced expiratory volume in one second. % predicted pre-BD FVC: Percent predicted pre-Bronchodilator Forced vital capacity. % predicted FEV1/FVC post-BD: Percent predicted post-Bronchodilator FEV1/FVC ratio. BD Response: Bronchodilator response as a percentage of pre-bronchodilator FEV1. Inhaled Steroids: respondents indicated the use of inhaled corticosteroids in the previous year. P-values computed with Chi-Square or Student’s t-Test

ISSN: 1465-993X