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Fig. 5 | Respiratory Research

Fig. 5

From: Altered immune surveillance of B and T cells in patients with persistent residual lung abnormalities 12 months after severe COVID-19

Fig. 5

Full recovery patients, but not those with persistent lung abnormalities, can down-regulate CD4 + GATA3 + T-cells as a response to polyclonal stimulus. Peripheral mononuclear cells are from patients FRG (black dots, n = 5) or PLAG (red square, n = 5), stimulated for 24 h with anti-CD3/CD28 (1 µg/mL). An unstimulated condition and isotype control were included as control stimulation. (a) The frequency of CD3 + cells (T lymphocytes) at baseline and (b) co-receptor CD4 and CD8 expression was evaluated, and (c) is shown in the graphic. (d) The Tbet + expression and (e) frequency were assessed in CD3 + CD4 + T-cells cultured with a polyclonal stimulus. (f) The GATA3 + expression and (g) frequency were assessed in CD3 + CD4 + T-cells cultured with a polyclonal stimulus. Data are represented as median and IQR values; each symbol represents an individual patient. The Kruskal-Wallis test performed statistical comparisons, ** p < 0.01, * p < 0.05

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Respiratory Research

ISSN: 1465-993X

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