Potential drug targets for asthma identified through mendelian randomization analysis

Respiratory Research

Table 2 Summary of reverse causality detection, bayesian co-localization analysis and phenotype scanning on seven potential causal proteins

Tissue	Protein	UniProt ID	SNP	Bidirectional MR (MR-IVW)^a	Steiger filtering	coloc.abf. PPH4	Previously reported associations
Plasma	IL1R1	P14778	rs7588201	1.038 (0.985–1.093)	Ture 1.201 × 10⁻⁸	0.016	Eczema ^b Allergic disease ^c
Plasma	IL7R	P16871	rs11957503	0.973 (0.941–1.007)	Ture 8.946 × 10⁻²¹	0.022	White blood cell ^b
Plasma	ECM1	Q16610;	rs13294	0.980 (0.944–1.017)	Ture 1.536 × 10⁻¹⁰⁷	0.953	Monocyte ^c Blood platelet ^c Atopic dermatitis ^b
Plasma	CD200R1	Q8TD46	rs6791672	0.986 (0.953–1.021)	Ture 5.767 × 10⁻¹¹	0.181	Eczema ^c Allergic rhinitis ^b
Plasma	ADAM19	Q9H013	rs7728609	0.980 (0.948–1.013)	Ture 3.876 × 10⁻¹⁹	0.0004	1 s forced expiratory volume ^c Peak expiratory flow ^c Age-related macular degeneration. ^b
CSF	IL-6 sRa	P08887	rs4129267	1.016 (0.953–1.021)	Ture 2.281 × 10⁻⁸⁸	0.966	Red blood cell Distribution width ^c Coronary artery disease. ^b
CSF	Layilin	Q6UX15	rs674230	0.954 (0.912–0.998)	Ture 4.868 × 10⁻²⁹	0.975	Allergic disease ^c

MR-IVW = Mendelian randomization with inverse variance weighted method; PP = posterior probability;
^a Odds ratios per SD increase in plasma protein levels and per 10-fold increase in CSF protein levels as asthma risk increased
^b SNP associated with traits directly
^c SNP associated with traits mediated by its proxy

ISSN: 1465-993X