Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease

Wang, Rui; Li, Yuanyuan; Jiang, Yuting; Liu, Xiaona; Feng, Hongqi; Jiao, Zhe; Li, Bingyun; Liu, Chang; Shen, Yuncheng; Chu, Fang; Zhu, Chenpeng; Sun, Dianjun; Zhang, Wei

doi:10.1186/s12931-024-03079-4

Table 6 Interaction between environmental exposure and haplotypes on COPD

From: Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease

Haplotype block(Gene)	Environment	Haplotypes	Environmental classification	RERI (95%CI)	SI (95%CI)	OR (95%CI)*	P-value
rs2808630-rs1205 (CRP)	Smoking*	TC + CC vs TT	Smoking index > 200 vs Smoking index ≤ 200	0.15 (− 0.40–0.69)	1.29 (0.44–3.79)	1.17 (0.72–1.88)	0.53
rs2808630-rs1205 (CRP)	Indoor fuel use@	TC + CC vs TT	Coal/Wood/Straw vs No fuel/Natural gas/Electricity	0.47 (− 0.32–1.25)	1.86 (0.28–12.44)	1.36 (0.57–3.37)	0.50
rs2808630-rs1205 (CRP)	Straw burning outdoor#	TC + CC vs TT	Yes vs No	0.29 (− 0.28–0.85)	1.56 (0.51–4.80)	1.17 (0.72–1.88)	0.53
rs2304225-rs11084376-rs8112766 (FCAR)	Smoking*	CCG + CGG + GGG vs CCA	Smoking index > 200 vs Smoking index ≤ 200	− 0.50 (− 1.04–0.05)	0.06 (1.81e⁻⁶–2.03e³)	0.69 (0.44–1.08)	0.11
rs2304225-rs11084376-rs8112766 (FCAR)	Indoor fuel use@	CCG + CGG + GGG vs CCA	Coal/Wood/Straw vs No fuel/Natural gas/Electricity	0,10 (− 0.63–0.83)	1.35 (0.07–26.20)	1.35 (0.54–3.55)	0.53
rs2304225-rs11084376-rs8112766 (FCAR)	Straw burning outdoor#	CCG + CGG + GGG vs CCA	Yes vs No	− 0.15 (− 0.68–0.39)	0.63 (0.16–2.54)	0.96 (0.58–1.57)	0.85
rs1865097-rs62123424 (FCAR)	Smoking*	AT + GT + AC vs CC	Smoking index > 200 vs Smoking index ≤ 200	− 0.05 (− 0.60–0.50)	0.88 (0.22–3.57)	0.97 (0.63–1.50)	0.89
rs1865097-rs62123424 (FCAR)	Indoor fuel use@	AT + GT + AC vs CC	Coal/Wood/Straw vs No fuel/Natural gas/Electricity	0,10 (− 0.63–0.83)	1.35 (0.07–26.20)	2.45 (0.95–6.98)	0.08
rs1865097-rs62123424 (FCAR)	Straw burning outdoor#	AT + GT + AC vs CC	Yes vs No	− 0.14 (− 0.73–0.45)	0.79 (0.31–1.98)	0.90 (0.56–1.46)	0.67
rs4656308-rs4656309-rs2165088 (FCGR2A)	Smoking*	CTG + TCA + TTA + TTG vs TCG	Smoking index > 200 vs Smoking index ≤ 200	− 0.08 (− 0.61–0.46)	0.78 (0.15–3.93)	0.97 (0.63–1.50)	0.90
rs4656308-rs4656309-rs2165088 (FCGR2A)	Indoor fuel use@	CTG + TCA + TTA + TTG vs TCG	Coal/Wood/Straw vs No fuel/Natural gas/Electricity	0,10 (− 0.63–0.83)	1.35 (0.07–26.20)	1.47 (0.61–3.56)	0.39
rs4656308-rs4656309-rs2165088 (FCGR2A)	Straw burning outdoor#	CTG + TCA + TTA + TTG vs TCG	Yes vs No	− 0.59 (− 1.31–0.13)	0.48 (0.26–0.89)	0.67 (0.42–1.06)	0.09

^*: Adjusted for Age, Education, Income, BMI, History of RD, History of CHD/CHF, History of CVD, Straw burning outdoor, Indoor fuel use
@: Adjusted for Age, Education, Income, BMI, History of RD, History of CHD/CHF, History of CVD, Smoking, Straw burning outdoor
^#: Adjusted for Age, Education, Income, BMI, History of RD, History of CHD/CHF, History of CVD, Smoking, Indoor fuel use

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