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Table 5 Interaction between Straw burning outdoor exposure and SNPs on COPD

From: Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease

SNP (Gene)

Genotype

RERI (95%CI)

SI (95%CI)

OR (95%CI)*

P-value

rs1205 (CRP)

C/T + C/C vs T/T

0.38 (− 0.34–1.11)

1.86 (0.26–13.33)

1.24 (0.63–2.42)

0.54

rs1130864 (CRP)

G/A + A/A vs G/G

0.77 (− 1.27–2.81)

1.82 (0.29–11.29)

1.25 (0.39–4.13)

0.71

rs2808630 (CRP)

C/T + C/C vs T/T

0.11 (− 0.78–1.00)

1.22 (0.23–6.50)

1.07 (0.50–2.29)

0.86

rs11084376 (FCAR)

CG + GG vs C/C

− 0.09 (− 0.83–0.64)

0.77 (0.14–4.39)

0.98 (0.51–1.90)

0.96

rs4806606 (FCAR)

A/G + G/G vs A/A

− 0.48 (− 1.36–0.39)

0.17 (0.00–16.51)

0.72 (0.33–1.58)

0.41

rs4806608 (FCAR)

A/G + G/G vs A/A

− 0.07 (− 0.84–0.70)

0.73 (0.03–18.33)

1.07 (0.47–2.49)

0.87

rs62123424 (FCAR)

T/C + T/T vs C/C

− 0.36 (− 1.36–0.63)

0.69 (0.31–1.53)

0.74 (0.38–1.44)

0.38

rs7259090 (FCAR)

A/G + A/A vs G/G

− 0.48 (− 1.46–0.51)

0.29 (0.02–4.24)

0.71 (0.31–1.67)

0.43

rs8112766 (FCAR)

A/G + G/G vs A/A

− 0.53 (− 1.47–0.41)

0.37 (0.10–1.31)

0.72 (0.37–1.39)

0.33

rs1865097 (FCAR)

A/G + A/A vs G/G

− 0.51 (− 1.57–0.55)

0.62 (0.30–1.31)

0.67 (0.34–1.30)

0.24

rs2304225 (FCAR)

CG + GG vs C/C

0.15 (− 0.75–1.05)

1.28 (0.25–6.68)

1.09 (0.52–2.31)

0.83

rs4656308 (FCGR2A)

C/T + C/C vs T/T

− 0.43 (− 1.31–0.45)

0.23 (0.01–7.34)

0.76 (0.34–1.71)

0.50

rs4656309 (FCGR2A)

T/C + T/T vs C/C

− 0.62 (− 1.82–0.57)

0.40 (0.14–1.12)

0.69 (0.33–1.45)

0.33

rs4657040 (FCGR2A)

T/C + C/C vs T/T

− 0.38 (− 1.29–0.53)

0.47 (0.10–2.25)

0.76 (0.37–1.58)

0.46

rs1801274 (FCGR2A)

A/G + G/G vs A/A

− 0.27 (− 1.14–0.60)

0.62 (0.20–1.91)

0.84 (0.43–1.64)

0.60

rs2165088 (FCGR2A)

G/A + A/A vs G/G

− 0.83 (− 2.05–0.38)

0.41 (0.14–1.22)

0.55 (0.26–1.13)

0.10

rs844 (FCGR2B)

A/G + A/A vs G/G

− 1.17 (− 2.38–0.05)

0.30 (0.11–0.77)

0.46 (0.24–0.90)

0.02

rs16827592 (FCGR2B)

T/G + G/G vs T/T

0.47 (− 0.30–1.23)

2.38 (0.22–25.45)

1.37 (0.69–2.73)

0.37

  1. The straw burning outdoor exposure is classified into Straw burning outdoor vs No Straw burning outdoor; Adjusted for Age, Education, Income, BMI, History of RD, History of CHD/CHF, History of CVD, Indoor fuel use, Smoking
  2. *: Multiplication interaction; P-value for Multiplication interaction
  3. The bolded content represents the statistically significant indicators and their statistical results and P-values