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Table 4 Interaction between indoor fuel use and SNPs on COPD

From: Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease

SNP (Gene)

Genotype

RERI (95%CI)

SI (95%CI)

OR (95%CI)*

P-value

rs1205 (CRP)

C/T + C/C vs T/T

0.41 (-0.73–1.56)

1.56 (0.17–13.94)

1.20 (0.33–4.18)

0.78

rs1130864 (CRP)

G/A + A/A vs G/G

2.45 (0.73–4.18)

− 4.57 (Na-Na)

1.39e6 (1.61e-11-Na)

0.97

rs2808630 (CRP)

C/T + C/C vs T/T

0.45 (− 0.63–1.53)

2.31 (0.04–140.48)

1.56 (0.41–6.85)

0.53

rs11084376 (FCAR)

CG + GG vs C/C

0.24 (− 0.69–1.16)

2.34 (0.00–4808.09)

1.54 (0.44–5.96)

0.51

rs4806606 (FCAR)

A/G + G/G vs A/A

0.25 (− 0.58–1.08)

− 1.17 (Na-Na)

2.01 (0.50–10.35)

0.35

rs4806608 (FCAR)

A/G + G/G vs A/A

− 0.17 (− 1.47–1.12)

0.68 (0.09–5.53)

1.02 (0.27–4.46)

0.97

rs62123424 (FCAR)

T/C + T/T vs C/C

0.62 (− 0.05–1.29)

− 1.51 (Na-Na)

2.15 (0.63–7.60)

0.22

rs7259090 (FCAR)

A/G + A/A vs G/G

− 0.45 (− 2.05–1.15)

0.53 (0.11–2.45)

0.77 (0.21–3.05)

0.70

rs8112766 (FCAR)

A/G + G/G vs A/A

− 0.37 (− 1.91–1.16)

0.60 (0.19–1.84)

0.85 (0.24–2.93)

0.80

rs1865097 (FCAR)

A/G + A/A vs G/G

0.63 (− 0.04–1.30)

− 1.54 (Na-Na)

2.17 (0.63–7.65)

0.22

rs2304225 (FCAR)

CG + GG vs C/C

0.37 (− 0.97–1.72)

1.69 (0.10–27.64)

1.37 (0.31–7.45)

0.69

rs4656308 (FCGR2A)

C/T + C/C vs T/T

− 0.71 (− 2.49–1.07)

0.38 (0.08–1.81)

0.64 (0.17–2.56)

0.51

rs4656309 (FCGR2A)

T/C + T/T vs C/C

0.39 (− 0.48–1.25)

0.27 (0.00–16.78)

2.00 (0.46–8.43)

0.34

rs4657040 (FCGR2A)

T/C + C/C vs T/T

− 0.09 (− 1.44–1.26)

0.87 (0.14–5.52)

1.02 (0.28–4.40)

0.98

rs1801274 (FCGR2A)

A/G + G/G vs A/A

0.46 (− 0.25–1.17)

− 0.66 (Na-Na)

2.05 (0.60–7.26)

0.26

rs2165088 (FCGR2A)

G/A + A/A vs G/G

0.21 (− 1.04–1.46)

1.36 (0.13–14.07)

1.22 (0.33–5.29)

0.77

rs844 (FCGR2B)

A/G + A/A vs G/G

− 0.37 (− 1.90–1.17)

0.65 (0.22–1.98)

0.82 (0.24–2.79)

0.74

rs16827592 (FCGR2B)

T/G + G/G vs T/T

0.02 (− 1.76–1.80)

1.02 (0.23–4.50)

0.89 (0.23–3.69)

0.87

  1. The indoor fuel use exposure is classified into Coal/Wood/Straw vs No fuel/Natural gas/Electricity; Adjusted for Age, Education, Income, BMI, History of RD, History of CHD/CHF, History of CVD, Smoking, Straw burning outdoor
  2. *: Multiplication interaction; P-value for Multiplication interaction
  3. The bolded content represents the statistically significant indicators and their statistical results and P-values