Table 3 Interaction between smoking and SNPs on COPD

rs1205*

(CRP)

T/T

Smoking index ≤ 200

Ref

C/T + C/C

Smoking index ≤ 200

1.27 (0.87–1.86)

0.22

T/T

Smoking index > 200

1.39 (0.86–2.25)

0.18

C/T + C/C

Smoking index > 200

1.81 (1.18–2.79)

0.01

rs1130864 ^@

(CRP)

G/G

No fuel/Natural gas/Electricity

Ref

G/A + A/A

No fuel/Natural gas/Electricity

1.39e⁻⁶ (NA-1.28e¹¹)

0.97

G/G

Coal/Wood/Straw

1.56 (0.83–3.04)

0.18

G/A + A/A

Coal/Wood/Straw

3.01 (1.39–6.745)

0.01

rs11084376*

(FCAR)

C/C

Smoking index ≤ 200

Ref

C/G + G/G

Smoking index ≤ 200

1.09 (0.75–1.59)

0.64

C/C

Smoking index > 200

1.89 (1.25–2.88)

<0.01

C/G + G/G

Smoking index > 200

1.11 (0.72–1.77)

0.65

rs844^#

(FCGR2B)

G/G

No straw burning outdoor

Ref

A/G + A/A

No straw burning outdoor

1.47 (0.84–2.60)

0.18

G/G

Straw burning outdoor

2.18 (1.39–3.46)

<0.01

A/G + A/A

Straw burning outdoor

1.49 (0.94–2.37)

0.09