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Table 5 Summary of studies assessing cost burden and healthcare resource utilisation in patients with JoRRP

From: "A systematic literature review of the epidemiology, clinical, economic and humanistic burden in recurrent respiratory papillomatosis”

Study

Country

Year of data collection

Parameter

Value [cost year]

Studies presenting cost data in patients with JoRRP

 Bishai 2000

US

1994

Annual medical costs

$42–67 m USD [NR]

Estimated cost per case

$29,946 USD [NR]

 Chesson 2012

US

2004–2007

Annual medical costs

$123 m USD [2010]

Cost per case

Mean (range): 150,000 (72,000–387,000) USD [2010]

 Derkay 1995

US

1993–1994

Total cost of surgical procedures

$109 m USD [NR]

Per surgical procedure

$6,593 USD [NR

 Narasimhan 2012

UK

2005–2011

Summative treatment cost among 14 patients

£225,000 [NR]

 Tam 2020

US

2011–2014 and 2008–2012

Medical cost in the first 2 years after diagnosis for patients with newly diagnosed JoRRP

Approx. $76,000 USD [2015]

(Medicaid patients)

Approx. $59,000 USD [2015]

(privately insured)

Studies presenting resource data in patients with JoRRP

 Armstrong 1999

US

1997–1998

Annual surgical treatments

Mean (range): 4.4 (0.2–19.3)

 Bishai 2000

US

1994

Number of office visits

(per surgery)

Mean (range): 3 (2.4–2.6)

 Derkay 1995

US

1993–1994

Lifetime papilloma operations

11–20 operations: 21%

21–40 operations: 16%

41–100 operations: 10%

 > 100 operations: 7%

 Reeves 2003

US

1996–2002

Annual surgical treatments

Mean (range): 5.1 (0.4–21.5)

 Amiling 2021

US

2015–2020

Lifetime surgeries

Median (IQR): 6 (3–13)

 So 2022

US

NR

RRP-related healthcare visit

0–2 visits: 84%

3–5 visits: 16%

 Nogueira 2021

Brazil

2008–2015

Number of surgeries

Mean (SD): 7.0 (5.71)

 Omland 2014

Norway

1987–2009

Annual surgical treatment

Median (IQR): 1.2 (0.5–3.4)

Mean (SD): 2.0 (2.1)

  1. AoRRP adult-onset recurrent respiratory papillomatosis, IQR Interquartile range, JoRRP juvenile onset recurrent respiratory papillomatosis, NR not reported, RRP Recurrent respiratory papillomatosis, SD standard deviation, USD US dollar