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Table 4 Symptomatic presentations among patients with JoRRP and AoRRP

From: "A systematic literature review of the epidemiology, clinical, economic and humanistic burden in recurrent respiratory papillomatosis”

Symptom

Proportion of patients, range

JoRRP

 Cough [64,65,66,67]

4–89%

 Dysphagia [65, 66, 68, 69]

1–16%

 Weak/abnormal crying [58, 70]

20–24%

 Difficulty speaking [67]

46–56%

 Difficulty breathing [66]

29%*

 Difficulty swallowing [58]

8%*

 Dysphonia [50, 69, 70]

80–100%

 Dysplasia [69, 71]

10–21%

 Dyspnea [50, 67,68,69,70]

44–96%

 Severe dyspnea [72, 73]

67–69%

 Failure to thrive [64]

26%*

 Horseness [58, 64,65,66, 74,75,76,77,78]

33–100%

 Raspy voice [67]

63–97%

 Respiratory difficulty [47, 58, 65]

27–66%

 Respiratory disorder [74]

50%*

 Respiratory distress [75, 78]

29–60%

 Severe airway obstruction [65, 66]

6–7%

 Shortness of breath [75]

40%*

 Snoring [66, 75]

1–40%

 Stridor [47, 58, 64,65,66,67, 75]

5–100%

 Throat pain [67]

13–22%

 Upper airway obstruction [64, 79]

42–100%

 Voice impairment [58, 80,81,82]

57–100%

 Noisy breath [75]

13%*

AoRRP

 Dysphagia [68, 69]

14–38%

 Dysphonia [68, 69]

63–100%

 Dysplasia [48, 59, 69, 83]

19–50%

 Dyspnea [68, 69]

13–20%

 Upper airway obstruction [79]

70%*

 Voice impairment [84,85,86,87]

100%*

  1. *Study does not report a range