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Fig. 1 | Respiratory Research

Fig. 1

From: Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway

Fig. 1

4µ8C attenuated lung injury and IRE1α-XBP1 axis in LPS-induced ALI. (A) Representative H&E staining images of mouse lung tissue exposed to LPS for different timepoint. Magnification 100×, scale bar = 100 μm. (B) Representative western blot of IRE1α, XBP1s and XBP1u, and densitometric analysis normalized to β-tubulin. (C) Experimental design. (D) Representative western blot of IRE1α, XBP1s and XBP1u, and densitometric analyses. (E) Representative H&E staining images of mice lung tissues. Magnification 100×, scale bar = 50 μm. (F) Lung injury scores according to the H&E staining images. (G-I) The total cell counts (G) and neutrophil cell number (H), and protein concentration (I) in BALF. Data are mean ± SEM, n = 4–6 for each group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Respiratory Research

ISSN: 1465-993X

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