A genome-wide association study of adults with community-acquired pneumonia

Respiratory Research

Table 1 Results of the sentinel variants independently associated with CAP

Variant	Position	p-value	MAF	OR [95% CI]	A1/A2	Rsq	Func.Gene	Nearest gene(s)
rs34955650	4:130254264	2.41 × 10^− 8	0.05	2.46 [1.80–3.38]	C/T	0.99	intergenic	C4orf33, LINC02466
rs213226	6:33209310	8.64 × 10^− 9	0.17	1.84 [1.49–2.26]	A/G	0.36	intergenic	RING1, HCG25
rs456261	6:33258443	4.00 × 10^− 28	0.02	8.23 [5.65–11.99]	G/A	0.33	intronic	PFDN6
rs2076775	6:33394253	7.26 × 10^− 10	0.14	0.50 [0.41–0.63]	C/G	0.36	intronic	SYNGAP1
rs117203606	11:42330132	2.90 × 10^− 8	0.11	0.21 [0.12–0.36]	G/A	Genotyped	intergenic	LINC02740, HNRNPKP3
rs45577437	20:32341041	1.21 × 10^− 14	0.44	0.46 [0.37–0.56]	C/T	Genotyped	exonic	ZNF341

Position: chromosome and base pair according to GRCh37/hg19; MAF: minor allele frequency in the study population; OR: odds ratio; CI: confidence interval; A1: Non-effect allele; A2: Effect allele; Rsq: Imputation R squared; Func.Gene: gene location

ISSN: 1465-993X