Table 1 Exposure conditions to emissions from HTPs, combustible cigarettes, and air (control)
From: Can switching from cigarettes to heated tobacco products reduce consequences of pulmonary infection?
Weeks 1–8 | Weeks 9–16 | |||
|---|---|---|---|---|
Cigarettes | HTP | Cigarettes | Cessation (Air) | |
Puffing protocol | ||||
Number of products used over 5 h | 60 cigarettes | 20 tobacco sticks | 60 cigarettes | -- |
Number of puff clusters over 5 h | 60 | 20 | 60 | -- |
Number of puffs per cluster | 8 | 12 | 8 | -- |
Total number of puffs taken over 5 h | 480 | 240 | 480 | -- |
Interval between puff clusters | 1 min | 9 min | 1 min | -- |
Airborne exposure | ||||
Airborne Nicotine (µg/m3) | 581.3 ± 420.1 | 196.3 ± 144.1 | 549.2 ± 301.4 | 17.7 ± 13.6 |
PM5.0 (mg/m3) | 10.5 ± 8.9 | 1.5 ± 7.2* | 11.3 ± 10.7* | < LOQ |
TPM (mg/m3) | 182.8 ± 69.6 | 35.1 ± 13.5* | 198.4 ± 73.1* | < LOQ |
Thirdhand exposure | ||||
Nicotine deposited on surface (mg/m2/5 h) | 0.3 ± 0.3 | 0.4 ± 0.4 | 0.2 ± 0.1 | < LOQ |
Nicotine deposited on fur (mg/m2/16 wks) | 3.2 ± 0.7 | 4.8 ± 1.9 | 2.8 ± 0.8 | < LOQ |
Systemic nicotine exposure | ||||
Serum cotinine in females (ng/mL)- | 39.5 ± 22.5 | 26.4 ± 13.6 | 24.0 ± 9.3 | < LOQ |
Serum cotinine in males (ng/mL) | 24.9 ± 17.8 | 22.3 ± 10.9 | 25.5 ± 11.5 | < LOQ |
Serum cotinine in female + male (ng/mL) | 31.4 ± 21.3 | 25.7 ± 13.2 | 24.4 ± 10.6 | < LOQ |