Fig. 2
From: Can switching from cigarettes to heated tobacco products reduce consequences of pulmonary infection?
Lung-endothelial damage induced at the end of inhalation exposure. At the end of exposures, intratracheal instillations of FITC-dextran were given to mice and the levels of FITC-dextran leaking into plasma were quantified one hour later to measure the extent of lung-endothelial damage as described in detail in methods. Panel A represents data from males + females combined, while panel B represents data as males versus females. Difference between two groups is considered significant at p < 0.05 and statistical significance of the difference between two groups is indicated with symbols **p < 0.01; ***p < 0.001; ****p < 0.0001 after performing non-parametric Kruskal-Wallis test with false discovery rate (FDR) correction for multiple comparisons by GraphPad Prism V.9 software (GraphPad; La Jolla, CA, USA). In each experiment 10 males and 10 females per exposure group were used. Results are depicted as mean ± SE