Fig. 7

Comparison of DE Genes and functional pathways in IAV-infected HLTEs detected at the tissue or the single cell level 9. A, B Venn diagrams illustrating the relationships between DE genes identified by bulk RNAseq and by scRNAseq in different cell types. A Bulk RNAseq vs. scRNAseq (pool of all cell types); B bulk RNAseq vs. scRNAseq (individual cell types indicated in the diagram). The arrow points to 6 mRNAs making up the core tissue response identified by bulk and scRNAseq. C GSEA of IAV infection based on the bulk RNAseq data or scRNAseq data. Hallmark pathways [41] are listed on the vertical axis in reverse alphabetical order (top to bottom). Significantly (FDR ≤ 0.05) enriched or depleted pathways are marked with triangles as indicated in the legend on the right