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Table 3 Association of blood co with serum CC16 in COPD patients

From: Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein

Variables

Continues blood Co (ppm)

P modification

Tertiles of blood Co (ppm)

P trend

Tertile 1 (<0.635)

Tertile 2 (0.635 ~ 1.230)

Tertile 3 (>1.230)

All participators

-0.340 (-0.475, -0.205)

<0.001

0 (Ref)

-0.177 (-0.261, -0.094)

-0.277 (-0.355, -0.199)

0.001

Smoking status

 

0.031

    
 

None

-0.219 (-0.972, -0.116)

 

0 (Ref)

-0.125 (-0.432, -0.025)

-0.312 (-0.439, -0.102)

0.012

 

Former

-0.284 (-0.859, -0.106)

 

0 (Ref)

-0.241 (-0.367, -0.115)

-0.382 (-0.512, -0.252)

0.006

 

Current

-0.471 (-0.624, -0.355)

 

0 (Ref)

-0.290 (-0.387, -0.193)

-0.500 (-0.599, -0.400)

0.001

Smoking amount (pack-year)

 

0.011

    
 

≤ 47.0

-0.220 (-0.865, -0.205)

 

0 (Ref)

-0.283 (-0.389, -0.176)

-0.463 (-0.559, -0.366)

0.011

 

>47.0

-0.244 (-0.373, -0.072)

 

0 (Ref)

-0.259 (-0.392, -0.125)

-0.448 (-0.607, -0.289)

0.008

Enrolled season

 

0.008

    
 

Spring

-0.630 (-1.004, -0.255)

 

0 (Ref)

-0.152 (-0.307, 0.002)

-0.237 (-0.408, 0.065)

0.025

 

Summer

-0.769 (-1.288, -0.250)

 

0 (Ref)

-0.256 (-0.463, -0.050)

-0.329 (-0.526, -0.132)

0.002

 

Autumn

-0.561 (-0.850, -0.273)

 

0 (Ref)

-0.318 (-0.461, -0.176)

-0.737 (-0.940, -0.534)

0.003

 

Winter

-0.216 (-0.488, 0.053)

 

0 (Ref)

-0.165 (-0.328, 0.001)

-0.439 (-0.610, 0.269)

0.044

Self-cooking

  

0.112

    
 

Yes

-0.216 (-0.568, 0.254)

 

0 (Ref)

-0.332 (-0.879, -0.012)

-0.452 (-1.128, -0.120)

0.055

 

No

-0.205 (-0.428, 0.373)

 

0 (Ref)

-0.215 (-0.659, 0.124)

-0.336 (-0.689, -0.021)

0.078

Hypertension

  

0.085

    
 

Yes

-0.269 (-0.321, 0.216)

 

0 (Ref)

-0.281 (-0.403, -0.158)

-0.517 (-0.641, -0.394)

0.021

 

No

-0.308 (-0.347, -0.025)

 

0 (Ref)

0.276 (0.173, 0.379)

-0.141 (-0.252, -0.031)

0.071

Coronary disease

  

0.135

    
 

Yes

-0.303 (-0.365, -0.240)

 

0 (Ref)

-0.174 (-0.330, -0.018)

-0.395 (-0.531, 0.259)

0.006

 

No

-0.292 (-0.527, -0.014)

 

0 (Ref)

-0.165 (-0.264, 0.066)

-0.432 (-0.523, -0.341)

0.017

ICS

  

0.066

    
 

Yes

-0.344 (-0.494, -0.195)

 

0 (Ref)

-0.325 (-0.726, 0.104)

-0.444 (-0.956, 0.032)

0.021

 

No

-0.399 (-0.807, 0.008)

 

0 (Ref)

-0.128 (-0.483, 0.227)

-0.482 (-0.767, -0.197)

0.076

  1. Models were adjusted for age, gender, enrolled season, smoking status, smoking amount, self-coking, hypertension, coronary disease, and ICS usage
  2. Bold values indicated statistical significance
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Respiratory Research

ISSN: 1465-993X

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