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Fig. 5 | Respiratory Research

Fig. 5

From: Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Fig. 5

Lev upregulates circUSP34-targeted miR-1298-mediated BMP/Smad axis to inhibit cell proliferation, migration and promote apoptosis in hypoxia-treated PASMCs. (A) The expression of BMPR2 in PASMCs was measured by WB. (B) The protein expression levels of BMPR2 in PASMCs under different treatment conditions were detected by WB. (C) The cell proliferation ability of PASMCs under different treatment conditions was examined by CCK-8. (D) The expression of Ki-67 in PASMCs was measured by IF. (E) Cell migration ability of PASMCs was tested by cell scratch assay. (F) Apoptosis of PASMCs was determined by flow cytometry. (G) WB was performed to test the protein expression levels of BMP4, p-Smad1/5/8, Id1 in PASMCs under different treatment conditions. Data are displayed for three individual experiments with mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Respiratory Research

ISSN: 1465-993X

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