Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis

Table 5 Top 10 most active proteases mapped to cleaved proteins. P-value and FDR describes significance of correlation between protease and FEV1pp.

Gene	Protease	No. Proteins	p-Value	FDR
ELANE	Neutrophil elastase	23	0.003	0.018
GZMM	Granzyme M	20	0.245	0.420
CTSD	Cathepsin D	19	0.233	0.412
CTSE	Cathepsin E	19	0.154	0.330
ASPRV1	Aspartic peptidase	18	0.166	0.346
BLMH	Bleomycin hydrolase	18	0.405	0.594
CELA1	Chymotrypsin like elastase 1	18	0.000	0.005
CTSG	Cathepsin G	18	0.001	0.010
PRTN3	Proteinase 3	18	0.000	0.000
ATG4B	Autophagy related 4B cysteine peptidase	17	0.785	0.890

ISSN: 1465-993X