Table 4 Pathways reflected in proteins whose degradation was associated with FEV1pp
Pathway | Number overlapping genes | Number pathway genes | P-value | Q-value |
|---|---|---|---|---|
SUMO E3 ligases SUMOylate target proteins | 15 | 15 (177) | 4.94E-06 | 0.00745 |
RMTs methylate histone arginines | 15 | 15 (74) | 4.94E-06 | 0.00745 |
SUMOylation | 15 | 15 (182) | 4.94E-06 | 0.00745 |
SUMOylation of chromatin organization proteins | 14 | 14 (72) | 1.27E-05 | 0.00745 |
HDMs demethylate histones | 14 | 14 (50) | 1.27E-05 | 0.00745 |
PKMTs methylate histone lysines | 14 | 14 (73) | 1.27E-05 | 0.00745 |
Deposition of new CENPA-containing nucleosomes at the centromere | 14 | 14 (43) | 1.27E-05 | 0.00745 |
Nucleosome assembly | 14 | 14 (43) | 1.27E-05 | 0.00745 |
HDACs deacetylate histones | 16 | 17 (94) | 2.08E-05 | 0.00883 |
HCMV Early Events | 16 | 17 (109) | 2.08E-05 | 0.00883 |