Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis

Table 2 Proteases significantly correlated with FEV1pp across the Somascan and two tandem mass tagging datasets.

UniProt ID	Protease Name	Mean correlation with FEV1pp	Combined p-value	FDR
Proteases with positive associations with FEV1pp
P14384	Carboxypeptidase M	0.4441	0.0000	0.0000
P00734	Prothrombin	0.3752	0.0000	0.0007
P00749	Urokinase-type plasminogen activator	0.3836	0.0004	0.0054
P20142	Gastricsin	0.3898	0.0007	0.0061
Proteases with negative associations with FEV1pp
P24158	Myeloblastin	−0.4621	0.0000	0.0002
Q9UKR3	Kallikrein-13	−0.3275	0.0000	0.0002
P07858	Cathepsin B	−0.3481	0.0001	0.0017
P53634	Dipeptidyl peptidase 1	−0.3155	0.0002	0.0028
Q9UNI1	Chymotrypsin-like elastase	−0.4757	0.0004	0.0053
Q9UBR2	Cathepsin Z	−0.2607	0.0006	0.0059
P14780	MMP9	−0.3391	0.0005	0.0059
P22894	MMP8	−0.3268	0.0011	0.0091
P08311	Cathepsin G	−0.3155	0.0014	0.0103
P42574	Caspase-3	−0.3534	0.0014	0.0103
P16519	Neuroendocrine convertase 2	−0.3044	0.0020	0.0136
P17655	Calpain-2 catalytic subunit	−0.1639	0.0036	0.0177
P25774	Cathepsin S	−0.2411	0.0033	0.0177
P08246	Neutrophile Elastase	−0.2988	0.0030	0.0177
P45974	Ubiquitin carboxyl-terminal hydrolase 5	−0.0465	0.0034	0.0177
P39900	Macrophage metalloelastase	−0.4033	0.0030	0.0177
P09958	Furin endoprotease	−0.3957	0.0037	0.0177
Q92851	Caspase-10	–0.0646	0.0061	0.0280

Proteases are ordered by FDR. Note that degree of correlation with FEV1pp and FDR magnitude do not necessarily align

ISSN: 1465-993X