Fig. 8
The correlation of clinical variables and lung microbiota in the bronchiectasis with FAO group. Heatmap showing spearman correlation between clinical variables and BAL microbiome in exacerbation subgroup and non-exacerbation subgroup. Clinical variables are grouped into three categories: clinical indexes, inflammatory indexes, and imaging indexes. Only those taxa that displayed at least one significant correlation (q < .01, following FDR correction) were selected. The color-coded matrix represents the Spearman correlation coefficient, with red indicating a positive correlation and blue indicating a negative correlation. FDRs are denoted: *q < 0.05; **q < 0.01; ***q < 0.001. The spearmans correlation revealed two oral taxa, Treponema socranskii and and Dialister invisus, in exacerbation group of BE-FAO were positively associated neutrophilic cytokines (BAL-IL 1β and BAL-IL 8). BAL Bronchoalveolar lavage, BE Bronchiectasis without fixed airflow obstruction, BE-FAO Bronchiectasis with fixed airflow obstruction, BMI Body Mass Index, BSI Bronchiectasis severity index, CAT COPD Assessment Test, COPD Chronic obstructive pulmonary disease, CRP C-reactive protein, FDR False discovery rate, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, LAV low-attenuation volume, mMRC modified Medical Research Council, IL-1β interleukin [IL]-1β, IL-6 interleukin [IL]-6, IL-8 interleukin [IL]-8, IL-18 interleukin [IL]-18, MCP-1 Monocyte chemoattractant protein-1, NETs Neutrophil extracellular traps, TNF-α tumor necrosis factor [TNF]-α